(11-02-12) C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study.

Cox AJ, Agarwal S, Herrington DM, Carr JJ, Freedman BI, Bowden DW.
Source
Center for Human Genomics Center for Diabetes Research Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC Division of Cardiology, Oakwood Hospital and Medical Center, Dearborn, MI Department of Internal Medicine - Cardiology Department of Radiologic Sciences Department of Internal Medicine - Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Abstract
 Aims: Although current American Heart Association guidelines address C-reactive protein concentration and cardiovascular disease risk, it remains unclear whether this paradigm is consistent across populations with differing disease burdens. Individuals with Type 2 diabetes mellitus represent one group at increased risk of cardiovascular disease and subsequent mortality. This study aimed to examine the relationship between C-reactive protein concentrations and risk for all-cause mortality in European Americans with Type 2 diabetes from the A total of 846 European Americans with Type 2 Diabetes Heart Study. Methods: diabetes and baseline measures of C-reactive protein were evaluated. Vital SD). ? years (mean 2.1 ? status was determined after a follow-up period of 7.3 C-reactive protein concentrations were compared between living and deceased subgroups along with other known risk factors for cardiovascular disease, including blood lipids. Logistic regression was performed to determine risk for mortality associated with increasing C-reactive protein concentrations. At follow-up 160 individuals (18.7%) were deceased. No significant Results: differences in baseline serum glucose or lipid measures were observed between living and deceased subgroups. Baseline C-reactive protein concentrations were 15.94) compared with the ? significantly higher in the deceased subgroup (9.37  mg/l; P 7.91 ? living subgroup (5.36<0.0001). Participants with C-reactive  mg/l were approximately two times more likely to protein concentrations of 3-10 be deceased at follow-up (OR 2.06; 95% CI 1.17-3.62); those with C-reactive protein >mg/l were more than five times more likely to be deceased (OR 10 This study documents the utility of 5.24; CI 2.80-9.38). Conclusions: C-reactive protein in predicting risk for all-cause mortality in European Americans with Type 2 diabetes and supports its use as a screening tool in risk prediction models. ? 2011 The Authors. Diabetic Medicine? 2011 Diabetes UK.
Source: Diabet Med. 2011 Dec 28. doi: 10.1111/j.1464-5491.2011.03560.x. [Epub ahead of print]

? 2011 The Authors. Diabetic Medicine ? 2011 Diabetes UK.

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