(13-03-12) Inverse association of serum 25-hydroxyvitamin d with markers of inflammation and suppression of osteoclastic activity in hemodialys

Inverse association of serum 25-hydroxyvitamin d with markers of inflammation and suppression of osteoclastic activity in hemodialysis patients.

Eleftheriadis T, Antoniadi G, Liakopoulos V, Stefanidis I, Galaktidou G.
Source
Nephrology Department, Medical School, University of Thessaly, Larissa and Research Institute, Theagenion Anticancer Hospital, Thessaloniki, Greece. [email protected].
Abstract
Introduction. In hemodialysis patients, 25-hydroxyvitamin D conversion to active 1,25-dihydroxyvitamin D by the kidneys is very limited. The expression of both vitamin D receptor and 1alpha-hydroxylase in cells of the immune system and in both osteoblasts and osteoclasts makes it possible that 25-hydroxyvitamin D could play an important role in both inflammation and bone metabolism acting in a autocrine and/or paracrine way in these patients. Materials and Methods. Thirty-three hemodialysis patients not under vitamin D receptor agonist treatment were enrolled into the study. Serum levels of 25-hydroxyvitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), receptor activator of nuclear factor-kappaB ligand (RANKL), and osteoprotegerin, as well as intact parathyroid hormone were assessed by immunoassays. Results. Regarding inflammation, 25-hydroxyvitamin D inversely correlated with both CRP and IL-6. Regarding bone metabolism, 25-hydroxyvitamin D was positively related to osteoprotegerin, but negatively to the RANKL. The latter could be the result of parathyroid hormone suppression by 25-hydroxyvitamin D, since 25-hydroxyvitamin D negatively correlated with parathyroid hormone, which in turn was positively related to RANKL. Conclusions. Serum 25-hydroxyvitamin D is inversely correlated with markers of inflammation and may suppress osteoclastic activity in hemodialysis patients.

Source: Iran J Kidney Dis. 2012 Mar;6(2):129-35.

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