(29-03-12) Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure

Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure (PROPRES), a randomized trial1,2,3
1. Karianna FM Teunissen-Beek,
2. Janneke Dopheide,
3. Johanna M Geleijnse,
4. Stephan JL Bakker,
5. Elizabeth J Brink,
6. Peter W de Leeuw, and
7. Marleen A van Baak
+Author Affiliations
1. 1From the Top Institute Food and Nutrition, Wageningen, Netherlands (KFMT-B, JD, JMG, SJLB, EJB, and MAvB; the Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, Netherlands (MAvB, JD, and KFMT-B); the Division of Human Nutrition, Wageningen University, Wageningen, Netherlands (JMG); the Department of Medicine, University Medical Center Groningen and University of Groningen, Groningen, Netherlands (SJLB); the Pharmacokinetics and Human Studies Group, Netherlands Organization for Applied Scientific Research, Zeist, Netherlands (EJB); and the Department of Medicine, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, Netherlands (PWdL).
+Author Notes
? ↵2 Supported by the Top Institute (TI) Food and Nutrition (project A-1003), Wageningen, Netherlands.
? ↵3 Address correspondence to KFM Teunissen-Beekman, PO Box 616, 6200 MD Maastricht, Netherlands. E-mail: [email protected].
Abstract
Background: Dietary protein intake may help to manage blood pressure (BP) and prevent complications associated with elevated BP.
Objective: The objective of this study was to determine whether 4 wk of increased protein intake (∼25% compared with ∼15% of energy intake that isoenergetically replaces carbohydrate intake) lowers office and daytime BP compared with increased carbohydrate intake.
Design: A randomized, double-blind, parallel study compared consumption of 3 ? 20 g protein/d (20% pea, 20% soy, 30% egg, and 30% milk-protein isolate) with 3 ? 20 g maltodextrin/d. Protein or maltodextrin were isoenergetically substituted for a sugar-sweetened drink. Primary outcomes were office and daytime BP. A total of 99 men and women [age range: 20?70 y; BMI (in kg/m2): 25?35] with untreated elevated BP (BP ≥130/85 and <160/100 mm Hg) were randomly assigned. Ninety-four completers (51 subjects in the maltodextrin group, 43 subjects in the protein group) were included in the analyses.
Results: Office systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 4.9 ? 1.7 mm Hg (P = 0.005) and 2.7 ? 1.3 mm Hg (P = 0.05) lower, respectively, in the protein group. Daytime SBP was 4.6 ? 1.7 mm Hg lower in the protein group (P = 0.006), whereas daytime DBP did not differ between groups (P = 0.37). Urinary sodium excretion was higher in the maltodextrin group (P = 0.004).
Conclusion: Increased protein intake, at the expense of maltodextrin, lowers BP in overweight adults with upper-range prehypertension and grade 1 hypertension. This trial was registered at www.trialregister.nl as NTR 1362.

Source:Am J Clin Nutr April 2012 vol. 95 no. 4 966-971

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.