(22-04-12) Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior.

Sartorius T, Ketterer C, Kullmann S, Balzer M, Rotermund C, Binder S,
Hallschmid M, Machann J, Schick F, Somoza V, Preissl H, Fritsche A, H?ring HU,
Hennige AM.
Source
Department of Internal Medicine, Division of Endocrinology, Diabetology, and
Vascular Disease, University of Tuebingen, Tuebingen, Germany.
Abstract
Fat and physical inactivity are the most evident factors in the pathogenesis
of obesity, and fat quality seems to play a crucial role for measures of
glucose homeostasis. However, the impact of dietary fat quality on brain
function, behavior, and sleep is basically unknown. In this study, mice were
fed a diet supplemented with either monounsaturated fatty acids (MUFAs) or
saturated fatty acids (SFAs) and their impact on glucose homeostasis,
locomotion, brain activity, and sleep behavior was evaluated. MUFAs and SFAs
led to a significant increase in fat mass but only feeding of SFAs was
accompanied by glucose intolerance in mice. Radiotelemetry revealed a
significant decrease in cortical activity in SFA-mice whereas MUFAs even
improved activity. SFAs decreased wakefulness and increased non-rapid eye
movement sleep. An intracerebroventricular application of insulin promoted
locomotor activity in MUFA-fed mice, whereas SFA-mice were resistant. In
humans, SFA-enriched diet led to a decrease in hippocampal and cortical
activity determined by functional magnetic resonance imaging techniques.
Together, dietary intake of MUFAs promoted insulin action in the brain with its
beneficial effects for cortical activity, locomotion, and sleep, whereas a
comparable intake of SFAs acted as a negative modulator of brain activity in
mice and humans.

Source: Diabetes. 2012 Apr 9. [Epub ahead of print]

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