(01-05-12) Relations between obesity, insulin resistance, and 25-hydroxyvitamin D1,2,3

1. Cynthia A Lamendola,
2. Danit Ariel,
3. David Feldman, and
4. Gerald M Reaven
+ Author Affiliations
1. 1From the Department of Medicine, Stanford University School of Medicine, Stanford, CA.
+ Author Notes
↵2 Supported in part by the NIH (NIH National Research Service Award 5 T32 DK 7217-36, and NIH/National Center for Research Resources Clinical and Translational Science Award number UL1 RR025744).
↵3 Address correspondence to GM Reaven, Falk CVRC, CV 287, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305. E-mail: [email protected].
Abstract
Background: Although low circulating 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and obesity, the relations between these 3 variables have not been completely resolved.
Objective: The objective was to compare circulating 25(OH)D concentrations in apparently healthy individuals who were matched for degree of obesity or insulin sensitivity.
Design: This was a case-control study in which 78 apparently healthy individuals were classified as being normal weight (NW) or obese (OB) on the basis of their BMI and as being insulin sensitive (IS) or insulin resistant (IR) on the basis of their steady state plasma glucose (SSPG) concentration during the insulin suppression test.
Results: Groups did not differ in terms of age, sex distribution, race, or mean (??SD) plasma 25(OH)D concentration. Values for 25(OH)D were 32 ?? 10, 30 ?? 10, and 28 ?? 8 ng/mL in NW-IS, OB-IS, and OB-IR groups, respectively. These concentrations were essentially identical when comparing IR with IS subjects matched for BMI or when comparing OB with NW subjects matched for SSPG. Concentrations of 25(OH)D ??30 ng/mL were somewhat more common in OB subjects than in NW subjects (54% compared with 35%), but SSPG concentrations were not different within either the IR or IS groups when subgroups with 25(OH)D concentrations ??30 or >30 ng/mL were compared.
Conclusions: In 78 individuals, 47% of whom were vitamin D deficient or insufficient (??30 ng/mL), 25(OH)D concentrations did not vary with differences in insulin sensitivity (SSPG concentration) when matched for BMI (OB-IR compared with OB-IS). Similarly, when matched for SSPG concentrations, plasma 25(OH)D concentrations were not different in NW or OB individuals (NW-IS compared with OB-IS).

Source: Am J Clin Nutr May 2012 vol. 95 no. 5 1055-1059

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.