(16-05-12) Vitamin D in the etiology and management of polycystic ovary syndrome.

Thomson RL, Spedding S, Buckley JD.
Source
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
Abstract
Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS), with the 67-85% of women with PCOS having serum concentrations of 25-hydroxy vitamin D (25OHD) less than 20 ng/ml. Vitamin D deficiency may exacerbate symptoms of PCOS, with observational studies showing lower 25OHD levels were associated with insulin resistance, ovulatory and menstrual irregularities, lower pregnancy success, hirsutism, hyperandrogenism, obesity and elevated CVD risk factors. There is some, but limited, evidence for beneficial effects of vitamin D supplementation on menstrual dysfunction and insulin resistance in women with PCOS. Vitamin D deficiency may play a role in exacerbating PCOS and there may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomised controlled trials are required to confirm the potential benefits ofvitamin D supplementation in this population. ? 2012 Blackwell Publishing Ltd.

Fonte : Clin Endocrinol (Oxf). 2012 May 10. doi: 10.1111/j.1365-2265.2012.04434.x. [Epub ahead of print]

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