(19-05-12) Higher predicted vitamin D status is associated with reduced risk of Crohn's disease.

Ananthakrishnan AN, Khalili H, Higuchi LM, Bao Y, Korzenik JR, Giovannucci EL,
Richter JM, Fuchs CS, Chan AT.
Source
Division of Gastroenterology, Massachusetts General Hospital and Harvard
Medical School, Boston, Massachusetts 02214, USA.
Abstract
BACKGROUND & AIMS:
Vitamin D influences innate immunity, which is believed to be involved in the
pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). However, data
examining vitamin D status in relation to risk of CD and UC are lacking.
METHODS:
We conducted a prospective cohort study of 72,719 women (age, 40-73 y)
enrolled in the Nurses' Health Study. In 1986, women completed an assessment of
diet and lifestyle, from which a 25-hydroxy vitamin D [25(OH)D] prediction
score was developed and validated against directly measured levels of plasma 25
(OH)D. Through 2008, we confirmed reported diagnoses of incident CD or UC
through medical record review. We used Cox proportional hazards modeling to
examine the hazard ratio (HR) for incident CD or UC after adjusting for
potential confounders.
RESULTS:
During 1,492,811 person-years of follow-up evaluation, we documented 122
incident cases of CD and 123 cases of UC. The median predicted 25(OH)D level
was 22.3 ng/mL in the lowest and 32.2 ng/mL in the highest quartiles. Compared
with the lowest quartile, the multivariate-adjusted HR associated with the
highest quartile of vitamin D was 0.54 (95% confidence interval [CI], 0.30-.99)
for CD (P(trend) = .02) and 0.65 (95% CI, 0.34-1.25) for UC (P(trend) = .17).
Compared with women with a predicted 25(OH)D level less than 20 ng/mL, the
multivariate-adjusted HR was 0.38 (95% CI, 0.15-0.97) for CD and 0.57 (95% CI,
0.19-1.70) for UC for women with a predicted 25(OH)D level greater than 30
ng/mL. There was a significant inverse association between dietary and
supplemental vitamin D and UC, and a nonsignificant reduction in CD risk.
CONCLUSIONS:
Higher predicted plasma levels of 25(OH)D significantly reduce the risk for
incident CD and nonsignificantly reduce the risk for UC in women.

Source: Gastroenterology. 2012 Mar;142(3):482-9. Epub 2011 Dec 9.

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