(29-06-06) Dietary restriction and oral administration of antioxidant and omega-3.

What are the effects on the clinical variables in a group of obese women?
Rondanelli M, Cestaro B, Cazzola R, Trotti R, Opizzi A, Ioannou A, Magnani B, Migliavacca A, Ferrari E.

Dipartimento di Medicina Interna e Terapia Medica, Cattedra di Geriatria, Universita degli Studi, Pavia, Italy.

BACKGROUND: Obesity is now recognized as a major risk factor for many pathologies. The state of obesity is associated with an increase in reactive oxygen species; persistent overconsumption of calories in the obese may be exposing them to excessive damage besides maintaining the state of obesity. It is possible that dietary modification and association with assumption of antioxidant and omega-3 oral integration contributes to a reduction in reactive oxygen species generation and a corresponding reduction in indexes of oxidative damage, including lipid peroxidation. METHODS: Given this back-ground, the pro/anti-oxidant balance, biochemical parameters and the body composition were studied in two groups of obese women: a first group of 10 obese women were studied before and after eight weeks of dietary restriction and a second group of 12 obese women were studied before and after eight weeks of dietary restriction and oral administration of antioxidant and omega-3. RESULTS: In summary, as regards the preliminary results of clinical outcome parameters, interestly enough the glicaemic levels fall markedly in association with both dietary restriction and oral integration with antioxidant and omega-3. Another important finding of this study is that of calcium levels and phase angle (measured by impedenzometry) increase in the group treated with dietary restriction and oral administration of antioxidant and omega-3. CONCLUSIONS: Studies that aimed to explore whether oxidative status predicts clinical outcome would provide important details on the putative link between oxidative status and state of obesity.


Minerva Gastroenterol Dietol. 2001 Dec;47(4):195-204.
PMID: 16493378 [PubMed - in process]

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