(27-06-12) Diabetes incidence does not differ between subjects with and without high depressive symptoms -5-year follow-up results

Diabetes incidence does not differ between subjects with and without high depressive symptoms-5-year follow-up results of the Heinz Nixdorf Recall Study.
Icks A, Albers B, Haastert B, Pechlivanis S, Bokhof B, Slomiany U, Erbel R, J?ckel KH, Kruse J, Nowotny B, Herder C, Giani G, Moebus S; for the Heinz Nixdorf Recall Study Investigative Group and the German BMBF Competence Network for Diabetes Mellitus.
Source
Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University D?sseldorf Department of Public Health, Faculty of Medicine, Heinrich Heine University D?sseldorf, D?sseldorf mediStatistica, Neuenrade, University Hospital of Essen Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen Clinic for Cardiology, University Hospital of Essen, Essen Clinic for Psychosomatic Medicine and Psychotherapy, Justus Liebig University, Giessen Clinic for Psychosomatic Medicine and Psychotherapy, Philipps University, Marburg Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University D?sseldorf, D?sseldorf, Germany.
Abstract
 Aims Cross-sectional studies have consistently reported evidence for an association between diabetes and depressive disorders. However, only limited prospective studies have examined this association, reporting conflicting results. In a population-based cohort study, we compared cumulative incidences of diabetes We between participants with and without high depressive symptoms. Method analysed the 5-year follow-up data from the German Heinz Nixdorf Recall study of 7.6) years, 3547 participants without diabetes at baseline [mean age 58.8 (sd 47.5% male]. Depressive symptoms were defined using the Centre for Epidemiologic 17). Diabetes (diagnosed or previously Studies Depression scale (cut point ≥ undetected) was identified by self-reported physician-diagnosed diabetes, medication and high blood glucose levels. We estimated 5-year cumulative incidences with 95% confidence intervals and fitted multiple logistic regression models to calculate the odds ratios, adjusted for age, sex, physical activity, The smoking, living with or without partner, and educational level. Results CI 6.3-12.8) in participants with cumulative incidence of diabetes was 9.2% (95% CI 8.0-10.0) in participants high depressive symptoms at baseline and 9.0% (95% without these symptoms. The age- and sex-adjusted odds ratio of diabetes in participants with depressive symptoms compared with those without was 1.13 CI 0.74-1.65)]. These results did CI 0.77-1.68; fully adjusted 1.11 (95% [95%  not substantially change in several additional sensitivity analyses. Conclusion Our study did not show a significantly increased risk of developing diabetes in individuals with high depressive symptoms compared with those without high depressive symptoms during a 5-year follow-up period. ? 2012 The Authors. Diabetic Medicine ? 2012 Diabetes UK.
? 2012 The Authors. Diabetic Medicine ? 2012 Diabetes UK.

Source: Diabet Med. 2012 Jun 4. doi: 10.1111/j.1464-5491.2012.03724.x. [Epub ahead of print]

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