(02-07-12) A Short-term Diet and Exercise Intervention Ameliorates Inflammation and Markers of Metabolic Health in Overweight/Obese Children.

Izadpanah A, Barnard RJ, Almeda AJ, Baldwin GC, Bridges SA, Shellman ER, Burant CF, Roberts CK.
Source
1University of California, Los Angeles.
Abstract
The present study was designed to examine the effects of short-term diet and exercise on markers of metabolic health, serum-stimulated production of inflammatory biomarkers from cultured monocytes and adipocytes, and serum lipomics. Twenty-one overweight/obese children (9 boys, 12 girls, age 13.0?0.5 yr, BMI 33.0?1.8 kg/m(2)) were placed on a 2-week ad libitum, high-fiber, low-fat diet and daily exercise regimen. Fasting serum samples were taken pre- and post-intervention for determination of cytokines, metabolic risk markers, and lipomics. Monocytes and adipocytes were incubated with pre- and post-intervention serum to investigate changes in cytokine secretion. Correlative associations were calculated followed by hierarchical clustering to determine relationships between fatty acid (FA) species and clinical biomarkers. Despite remaining overweight/obese, interleukin (IL)-6, IL-8, TNF?, PAI-1, resistin, amylin, leptin, insulin, and IL-1ra decreased and adiponectin increased. Culture studies indicated decreases in monocyte secretion of IL-6, TNF-?, and IL-1? and adipocyte secretion of IL-6. Lipomic analysis revealed a decrease in total lipids and decreases in saturated FAs and an increase in 18:1/18:0. In general, Pearson's correlations revealed that inflammatory markers are negatively associated with a cluster of polyunsaturated FAs and positively correlated with several saturated FAs. These results indicate significant modification of multiple indices of metabolic health with short-term, rigorous lifestyle modification in overweight/obese children prior to obesity reversal.

Source: Am J Physiol Endocrinol Metab. 2012 Jun 19. [Epub ahead of print]

PMID:
22713506
[PubMed - as supplied by publisher]

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