(02-07-12) Cross-sectional study of conjugated linoleic acid in adipose tissue and risk of diabetes

1,2,3
1. Nelsy Castro-Webb,
2. Edward A Ruiz-Narv?ez, and
3. Hannia Campos
+ Author Affiliations
1. 1From the Department of Nutrition, Harvard School of Public Health, Boston, MA (NC-W and HC); the Slone Epidemiology Center at Boston University, Boston, MA (EAR-N); the Department of Epidemiology, Boston University School of Public Health, Boston, MA (EAR-N); and the Centro Centroamericano de Poblaci?n, Universidad de Costa Rica, San Pedro, Costa Rica (HC).
+ Author Notes
↵2 Supported by the NIH (grants HL49086 and HL60692).
↵3 Address correspondence to Hannia Campos, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115. E-mail: [email protected].
Abstract
Background: Some experimental studies on conjugated linoleic acid (CLA) and insulin regulation suggested that CLA could be associated with risk of diabetes, but epidemiologic studies are lacking.
Objective: The aim of the study was to test whether the amount of CLA in adipose tissue is associated with risk of diabetes.
Design: A cross-sectional design was used to test the study hypothesis in 232 adults with diabetes and 1512 adults without diabetes who lived in Costa Rica. The cis-9, trans-11 and trans-10, cis-12 CLA isomers in adipose tissue and 48 other fatty acids were assessed by using gas chromatography. Prevalence ratios (PRs) and 95% CIs were estimated by using Poisson regression adjusted for potential confounders.
Results: The mean (?SD) percentage of total fatty acids of CLA for the cis-9, trans-11 isomer in adipose tissue was 0.57 ? 0.18% in adults without diabetes and 0.53 ? 0.17% in adults with diabetes (P = 0.0078). The trans-10, cis-12 CLA isomer was not detected in adipose tissue. The cis-9, trans-11 CLA isomer was associated with a lower risk of diabetes. In comparison with the first quintile, the PR (95% CI) for the fifth quintile was 0.48 (0.31, 0.76) (P-trend = 0.0005) in the basic and 0.46 (0.29, 0.72) (P-trend = 0.0002) in the multivariable model. Additional adjustment for other fatty acids in adipose tissue including trans-9 16:1, which is a fatty acid that was previously associated with diabetes, did not modify the results.
Conclusion: The observed inverse association between the cis-9, trans-11 CLA in adipose tissue and diabetes risk is consistent with the hypothesis that CLA may be involved in insulin regulation.

Source: Am J Clin Nutr July 2012 vol. 96 no. 1 175-181

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