(06-08-12) Caloric restriction may reverse age-related autonomic decline in humans.

Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L.
Source
HRV Laboratory, Washington University School of Medicine, St. Louis, MO, USA Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO, USA Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy Department of Experimental Medicine, University of Rome 'La Sapienza', Rome, Italy Department of Medicine, Salerno University School of Medicine, Salerno, Italy CEINGE Biotecnologie Avanzate, Napoli, Italy.
Abstract
Caloric restriction (CR) retards aging in laboratory rodents. No information is available on the effects of long-term CR on physiologic markers of aging and longevity in humans. Heart rate variability (HRV) is a marker for cardiac autonomic functioning. The progressive decline in HRV with aging and the association of higher HRV with better health outcomes are well established. Heart rate variability assessment is a reliable tool by which the effects of CR on autonomic function can be assessed. Time- and frequency-domain analyses years and 20 age-matched compared 24-h HRV in 22 CR individuals aged 35-82 controls eating Western diets (WD). The CR group was significantly leaner than the WD group. Heart rate was significantly lower, and virtually, all HRV values  were significantly higher in the CR group than in the WD group (P<0.002).  Heart rate variability in the CR individuals was comparable with published norms years younger. In addition, when differences in heart for healthy individuals 20 rate (HR) and HRV between CR and WD were compared with previously published changes in HRV induced in healthy adults given atenolol, percent differences in each measure were generally similar in direction and magnitude and suggested declines in sympathetic and increases in parasympathetic modulation of HR and increased circadian variability associated with CR. These findings provide evidence that CR has direct systemic effects that counter the expected age-associated changes in autonomic function so that HRV indexes in CR years younger eating WDs. individuals are similar to those of individuals 20

Source: Aging Cell. 2012 Aug;11(4):644-650. doi: 10.1111/j.1474-9726.2012.00825.x. Epub 2012 May 21.

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