(29-08-12) Caffeine Intake and Semen Quality in a Population of 2,554 Young Danish Men

Tina Kold Jensen*, Shanna H. Swan, Niels E. Skakkeb?k, Sanne Rasmussen, and Niels J?rgensen
* Correspondence to Prof. Tina Kold Jensen, University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9,
2100 Copenhagen ?, Denmark (e-mail: [email protected]).
Initially submitted August 19, 2009; accepted for publication January 8, 2010.
The authors examined the association between semen quality and caffeine intake among 2,554 young Danish
men recruited when they were examined to determine their fitness for military service in 2001?2005. The men
delivered a semen sample and answered a questionnaire including information about caffeine intake from various
sources, from which total caffeine intake was calculated. Moderate caffeine and cola intakes (101?800 mg/day
and _14 0.5-L bottles of cola/week) compared with low intake (_100 mg/day, no cola intake) were not associated
with semen quality. High cola (>14 0.5-L bottles/week) and/or caffeine (>800 mg/day) intake was associated with
reduced sperm concentration and total sperm count, although only significant for cola. High-intake cola drinkers
had an adjusted sperm concentration and total sperm count of 40 mill/mL (95% confidence interval (CI): 32, 51) and
121 mill (95% CI: 92, 160), respectively, compared with 56 mill/mL (95% CI: 50, 64) and 181 mill (95% CI: 156, 210)
in non-cola-drinkers, which could not be attributed to the caffeine they consumed because it was <140 mg/day.
Therefore, the authors cannot exclude the possibility of a threshold above which cola, and possibly caffeine,
negatively affects semen quality. Alternatively, the less healthy lifestyle of these men may explain these findings.
?

Source: The Author 2010. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of
Public Health. All rights reserved. For permissions, please e-mail: [email protected].
American Journal of Epidemiology
Vol. 171, No. 8
DOI: 10.1093/aje/kwq007
Advance Access publication:
March 25, 2010

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