(25-09-12) Recent Trends in the Prevalence of Crohn's Disease and Ulcerative Colitis in a Commercially Insured US Population.

Kappelman MD, Moore KR, Allen JK, Cook SF.

PURPOSE:
Most US inflammatory bowel disease (IBD) epidemiology studies conducted to
date have sampled small, geographically restricted populations and have not
examined time trends. The aim of our study was to determine the prevalence of
Crohn's disease (CD) and ulcerative colitis (UC) in a commercially insured US
population and compare prevalences across sociodemographic characteristics and
time.
METHODS:
Using claims data from approximately 12 million Americans, we performed three
consecutive 2-year cross-sectional studies. Cases of CD and UC were identified
using a previously described algorithm. Prevalence was estimated by dividing
cases by individuals in the source population. Logistic regression was used to
compare prevalences by region, age, and sex.
RESULTS:
In 2009, the prevalences of CD and UC in children were 58 [95 % confidence
interval (CI) 55-60] and 34 (95 % CI 32-36), respectively. In adults, the
respective prevalences were 241 (95 % CI 238-245) and 263 (95 % CI 260-266).
Data analysis revealed that IBD prevalences have slightly increased over time.
Based on census data, an estimated 1,171,000 Americans have IBD (565,000 CD and
593,000 UC).
CONCLUSIONS:
Analysis of the epidemiological data revealed an increasing burden of IBD in
recent years, which may be used to inform policy.


Source: Dig Dis Sci. 2012 Aug 29. [Epub ahead of print]

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