(08-07-06) Can adverse effects of dietary fat intake be overestimated as a consequence of dietary fat underreporting?

Heitmann BL, Lissner L.

Department of Internal Medicine, Sahlgrenska University Hospital, Gothenborg University, Gothenborg, Sweden.

Objective: To describe the consequences of systematic reporting bias by the obese for diet-disease relationships.Design: The present report used 24-hour urinary nitrogen and estimates of 24-hour energy expenditure to assess error in diet reporting, and examined the consequence of accounting for this error for associations between dietary fat intake and serum low-density lipoprotein (LDL)-cholesterol.Setting: Sub-study to the Danish MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) project, carried out in 1987-1988.Subjects: A random sub-sample of the adult Danish male population (n=152).Results: Correcting dietary fat for underreporting error weakened, rather than strengthened, the association between dietary fat intake and LDL-cholesterol by reducing the slope of the regression from beta=3.4, P=0.02 to beta=2.7, P=0.04.Conclusion: This example illustrates that systematic underreporting of dietary fat by high-risk groups such as the obese may produce an overestimated association. These results imply that previous epidemiological studies showing a positive association between percentage of energy from fat and other health outcomes, e.g. cancer and heart disease, may have overestimated the negative effects of a high-fat diet. If we were able to correctly assess dietary fat intake in general populations, recommendations for fat intake may be more liberal than the 30% suggested today. Improved assessment of fat intake in epidemiological studies is necessary for future development of evidence-based recommendations for diet and health .

PMID: 16372929 [PubMed - in process]
Public Health Nutr. 2005 Dec;8(8):1322-7.

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