(08-07-06) Visceral adiposity and endothelial lipase.

Paradis ME, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Deshaies Y, Bergeron J, Archer WR, Couture P, Bergeron N, Lamarche B.

Nutraceuticals and Functional Foods Institute, Laval University, Quebec, Canada.; Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, USA.; Molecular Endocrinology and Oncology Research Center, Quebec, Canada.; Hopital Laval Research Center, Faculty of Medicine, Laval University, Quebec, Canada.; Lipid Research Center, CHUL Research Center, Quebec, Canada.; College of Pharmacy, Touro University - California; Vallejo, CA, USA.

Context: Over-expression of endothelial lipase (EL) has been shown to reduce plasma HDL-C levels in animal models. However, the extent to which EL contributes to modulate the deteriorated HDL profile observed in obesity in humans is less clear. Objectives: The objectives of this study were to investigate the association between levels of obesity and visceral adiposity in particular and plasma EL concentrations. Methods: Post-heparin plasma EL concentrations were measured by ELISA and visceral adiposity by computed tomography in a sample of 80 sedentary men in good health. EL mRNA levels in abdominal sc and omental adipose tissues obtained during abdominal hysterectomies were measured in another sample of 14 women. Results: Plasma EL levels were positively correlated with body mass index (R=0.46, P < 0.0001), visceral adipose tissue accumulation (R=0.44, P < 0.0001) and with a pro-atherogenic lipid profile including increased plasma cholesterol and triglycerides. However, EL mRNA levels were similar in sc and in omental AT and were 10 000-fold lower than LPL mRNA levels in those tissues. Conclusion: Increased visceral adiposity is significantly correlated with elevated plasma EL levels, but this association is unlikely to be causal and may reflect other common metabolic alterations.

J Clin Endocrinol Metab. 2006 Jun 13; [Epub ahead of print]

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