(21-10-12) Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort.

Buckland G, Travier N, Barricarte A, Ardanaz E, Moreno-Iribas C, S?nchez MJ,
Molina-Montes E, Chirlaque MD, Huerta JM, Navarro C, Redondo ML, Amiano P,
Dorronsoro M, Larra?aga N, Gonzalez CA.
Source
Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research
Programme, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via 199-203,
Barcelona 08907, Spain.
Abstract
Olive oil is well known for its cardioprotective properties; however,
epidemiological data showing that olive oil consumption reduces incident CHD
events are still limited. Therefore, we studied the association between olive
oil and CHD in the European Prospective Investigation into Cancer and Nutrition
(EPIC) Spanish cohort study. The analysis included 40 142 participants (38 %
male), free of CHD events at baseline, recruited from five EPIC-Spain centres
from 1992 to 1996 and followed up until 2004. Baseline dietary and lifestyle
information was collected using interview-administered questionnaires. Cox
proportional regression models were used to assess the relationship between
validated incident CHD events and olive oil intake (energy-adjusted quartiles
and each 10 g/d per 8368 kJ (2000 kcal) increment), while adjusting for
potential confounders. During a 10?4-year follow-up, 587 (79 % male) CHD events
were recorded. Olive oil intake was negatively associated with CHD risk after
excluding dietary mis-reporters (hazard ratio (HR) 0?93; 95 % CI 0?87, 1?00 for
each 10 g/d per 8368 kJ (2000 kcal) and HR 0?78; 95 % CI 0?59, 1?03 for upper
v. lower quartile). The inverse association between olive oil intake (per 10
g/d per 8368 kJ (2000 kcal)) and CHD was more pronounced in never smokers (11 %
reduced CHD risk (P = 0?048)), in never/low alcohol drinkers (25 % reduced CHD
risk (P < 0?001)) and in virgin olive oil consumers (14 % reduced CHD risk (P =
0?072)). In conclusion, olive oil consumption was related to a reduced risk of
incident CHD events. This emphasises the need to conserve the traditional
culinary use of olive oil within the Mediterranean diet to reduce the CHD
burden.

Source: Br J Nutr. 2012 Sep 25:1-8. [Epub ahead of print]

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