(31-10-12) Sugar-Sweetened Beverages and Genetic Risk of Obesity.

Qi Q, Chu AY, Kang JH, Jensen MK, Curhan GC, Pasquale LR, Ridker PM, Hunter
DJ, Willett WC, Rimm EB, Chasman DI, Hu FB, Qi L.
Source
From the Departments of Nutrition (Q.Q., M.K.J., D.J.H., W.C.W., E.B.R., F.B.
H., L.Q.) and Epidemiology (G.C.C., D.J.H., W.C.W., E.B.R., F.B.H.), Harvard
School of Public Health; and the Divisions of Preventive Medicine (A.Y.C., P.M.
R., D.I.C.), Cardiovascular Disease (P.M.R.), and Genetics (D.I.C.), and the
Channing Division of Network Medicine (J.H.K., G.C.C., L.R.P., D.J.H., W.C.W.,
E.B.R., F.B.H., L.Q.), Department of Medicine, Brigham and Women's Hospital and
Harvard Medical School; and the Department of Ophthalmology (L.R.P.),
Massachusetts Eye and Ear Infirmary, Harvard Medical School - all in Boston.
Abstract
Background Temporal increases in the consumption of sugar-sweetened beverages
have paralleled the rise in obesity prevalence, but whether the intake of such
beverages interacts with the genetic predisposition to adiposity is unknown.
Methods We analyzed the interaction between genetic predisposition and the
intake of sugar-sweetened beverages in relation to body-mass index (BMI; the
weight in kilograms divided by the square of the height in meters) and obesity
risk in 6934 women from the Nurses' Health Study (NHS) and in 4423 men from the
Health Professionals Follow-up Study (HPFS) and also in a replication cohort of
21,740 women from the Women's Genome Health Study (WGHS). The genetic-
predisposition score was calculated on the basis of 32 BMI-associated loci. The
intake of sugar-sweetened beverages was examined prospectively in relation to
BMI. Results In the NHS and HPFS cohorts, the genetic association with BMI was
stronger among participants with higher intake of sugar-sweetened beverages
than among those with lower intake. In the combined cohorts, the increases in
BMI per increment of 10 risk alleles were 1.00 for an intake of less than one
serving per month, 1.12 for one to four servings per month, 1.38 for two to six
servings per week, and 1.78 for one or more servings per day (P<0.001 for
interaction). For the same categories of intake, the relative risks of incident
obesity per increment of 10 risk alleles were 1.19 (95% confidence interval
[CI], 0.90 to 1.59), 1.67 (95% CI, 1.28 to 2.16), 1.58 (95% CI, 1.01 to 2.47),
and 5.06 (95% CI, 1.66 to 15.5) (P=0.02 for interaction). In the WGHS cohort,
the increases in BMI per increment of 10 risk alleles were 1.39, 1.64, 1.90,
and 2.53 across the four categories of intake (P=0.001 for interaction); the
relative risks for incident obesity were 1.40 (95% CI, 1.19 to 1.64), 1.50 (95%
CI, 1.16 to 1.93), 1.54 (95% CI, 1.21 to 1.94), and 3.16 (95% CI, 2.03 to
4.92), respectively (P=0.007 for interaction). Conclusions The genetic
association with adiposity appeared to be more pronounced with greater intake
of sugar-sweetened beverages. (Funded by the National Institutes of Health and
others.).

Source: N Engl J Med. 2012 Sep 21. [Epub ahead of print]

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