(05-11-12) Diabetes and breast cancer risk: a meta-analysis.

Boyle P, Boniol M, Koechlin A, Robertson C, Valentini F, Coppens K, Fairley
LL, Boniol M, Zheng T, Zhang Y, Pasterk M, Smans M, Curado MP, Mullie P,
Gandini S, Bota M, Bolli GB, Rosenstock J, Autier P.
Source
International Prevention Research Institute, 95 cours Lafayette, 69006 Lyon,
France.
Abstract
Background:The potential of an increased risk of breast cancer in women with
diabetes has been the subject of a great deal of recent research.Methods:A meta-
analysis was undertaken using a random effects model to investigate the
association between diabetes and breast cancer risk.Results:Thirty-nine
independent risk estimates were available from observational epidemiological
studies. The summary relative risk (SRR) for breast cancer in women with
diabetes was 1.27 (95% confidence interval (CI), 1.16-1.39) with no evidence of
publication bias. Prospective studies showed a lower risk (SRR 1.23 (95% CI,
1.12-1.35)) than retrospective studies (SRR 1.36 (95% CI, 1.13-1.63)). Type 1
diabetes, or diabetes in pre-menopausal women, were not associated with risk of
breast cancer (SRR 1.00 (95% CI, 0.74-1.35) and SRR 0.86 (95% CI, 0.66-1.12),
respectively). Studies adjusting for body mass index (BMI) showed lower
estimates (SRR 1.16 (95% CI, 1.08-1.24)) as compared with those studies that
were not adjusted for BMI (SRR 1.33 (95% CI, 1.18-1.51)).Conclusion:The risk of
breast cancer in women with type 2 diabetes is increased by 27%, a figure that
decreased to 16% after adjustment for BMI. No increased risk was seen for women
at pre-menopausal ages or with type 1 diabetes.

Source: British Journal of Cancer
advance online publication, 20 September 2012; doi:10.1038/bjc.2012.414 www.
bjcancer.com.

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