(11-11-12) High-polyphenol chocolate reduces endothelial dysfunction and oxidative stress ....

High-polyphenol chocolate reduces endothelial dysfunction and oxidative stress during acute transient hyperglycaemia in Type 2 diabetes: a pilot randomized controlled trial.

Mellor DD, Madden LA, Smith KA, Kilpatrick ES, Atkin SL.
Source
Department of Clinical Science, University of Chester, Chester, U.K.
Abstract
AIMS:
To investigate the effects of high-polyphenol chocolate upon endothelial
function and oxidative stress in Type 2 diabetes mellitus during acute
transient hyperglycaemia induced following a 75-g oral glucose challenge.
METHODS:
Ten subjects with Type 2 diabetes underwent a double-blinded randomized
controlled crossover study. A 75-g oral glucose load was used to induce
hyperglycaemia, which was administered to participants 60 min after they had
ingested either low (control) or high-polyphenol chocolate. Participants
undertook testing at weekly intervals, following an initial cocoa-free period.
Endothelial function was assessed by both functional [reactive hyperaemia
peripheral artery tonometry (EndoPAT-2000) and serum markers (including
intercellular adhesion molecule 1, P-selectin and P-selectin glycoprotein
ligand 1]. Urinary 15-F2t-isoprostane adjusted for creatinine was used as an
oxidative stress marker. Measurements were made at baseline and 2 h post-
ingestion of the glucose load.
RESULTS:
Prior consumption of high-polyphenol chocolate before a glucose load improved
endothelial function (1.7 ? 0.1 vs. 2.3 ? 0.1%, P = 0.01), whereas prior
consumption of control chocolate resulted in a significant increase in
intercellular adhesion molecule 1 (321.1 ? 7.6 vs. 373.6 ? 10.5 ng/ml, P =
0.04) and 15-F2t-isoprostane (116.8 ? 5.7 vs. 207.1 ? 5.7 mg/mol, P = 0.02).
Analysis of percentage changes from baseline comparing control and high-
polyphenol chocolate showed a significant improvement for high-polyphenol
chocolate in both measures of endothelial function (P < 0.05) and for urinary
15-F2t-isoprostane (P = 0.04).
CONCLUSION:
High-polyphenol chocolate protected against acute hyperglycaemia-induced
endothelial dysfunction and oxidative stress in individuals with Type 2
diabetes mellitus. ? 2012 The Authors. Diabetic Medicine ? 2012 Diabetes UK.
?
Source: Diabet Med. 2012 Oct 6. doi: 10.1111/dme.12030. [Epub ahead of print]

2012 The Authors. Diabetic Medicine ? 2012 Diabetes UK.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.