(26-01-13) Long term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize

Gilles-Eric S?ralini a,⇑, Emilie Clair a, Robin Mesnage a, Steeve Gress a, Nicolas Defarge a,
Manuela Malatesta b, Didier Hennequin c, Jo?l Spiroux de Vend?mois a
a University of Caen, Institute of Biology, CRIIGEN and Risk Pole, MRSH-CNRS, EA 2608, Esplanade de la Paix, Caen Cedex 14032, France
b University of Verona, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Verona 37134, Italy
c University of Caen, UR ABTE, EA 4651, Bd Mar?chal Juin, Caen Cedex 14032, France
a r t i c l e i n f o
Article history:
Received 11 April 2012
Accepted 2 August 2012
Available online 19 September 2012
a b s t r a c t
The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated
with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats. In
females, all treated groups died 2?3 times more than controls, and more rapidly. This difference was visible
in 3 male groups fed GMOs. All results were hormone and sex dependent, and the pathological profiles
were comparable. Females developed large mammary tumors almost always more often than and
before controls, the pituitary was the second most disabled organ; the sex hormonal balance was modified
by GMO and Roundup treatments. In treated males, liver congestions and necrosis were 2.5?5.5
times higher. This pathology was confirmed by optic and transmission electron microscopy. Marked
and severe kidney nephropathies were also generally 1.3?2.3 greater. Males presented 4 times more large
palpable tumors than controls which occurred up to 600 days earlier. Biochemistry data confirmed very
significant kidney chronic deficiencies; for all treatments and both sexes, 76% of the altered parameters
were kidney related. These results can be explained by the non linear endocrine-disrupting effects of
Roundup, but also by the overexpression of the transgene in the GMO and its metabolic consequences.
_

Source: Food and Chemical Toxicology 50 (2012) 4221?4231

2012 Elsevier Ltd. All rights reserved.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.