(17-02-13) Intakes of long-chain omega-3 (n−3) PUFAs and fish in relation to incidence of asthma among American young adults

Intakes of long-chain omega-3 (n−3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study1,2,3
1. Jingjing Li,
2. Pengcheng Xun,
3. Daisy Zamora,
4. Akshay Sood,
5. Kiang Liu,
6. Martha Daviglus,
7. Carlos Iribarren,
8. David Jacobs Jr,
9. James M Shikany, and
10. Ka He
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Author Affiliations
1. 1From the Departments of Epidemiology (JL) and Nutrition (DZ), Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC; the University of New Mexico, Health Sciences Center, School of Medicine, Albuquerque, NM (AS); the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (KL and MD); the Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA (CI); the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (DJ); the Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL (JMS); and the Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN (PX and KH).
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Author Notes
? ↵2 Supported in part by grant R01HL081572. The CARDIA study was supported by grants N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung, and Blood Institute.
? ↵3 Address correspondence to K He, Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, 1025 E Seventh Street, C034, Bloomington, IN 47405. E-mail: [email protected].
Abstract
Background: Although long-chain ?-3 (n−3) PUFAs (LC?3PUFAs) have been linked to the prevention of some inflammatory disorders, little is known about the association between these fatty acids and incidence of asthma.
Objective: The objective was to prospectively investigate the association between LC?3PUFAs and fish intake and incidence of asthma among American young adults.
Design: A 20-y follow-up longitudinal analysis was conducted in a biracial cohort of 4162 Americans, aged 18?30 y, with a history of asthma at baseline in 1985. Diet was assessed by a validated interviewer-administered quantitative food-frequency questionnaire at the examinations in 1985, 1992, and 2005. Incident self-reported asthma was defined as having a physician diagnosis of asthma and/or the use of asthma medications between 1985 and 2005.
Results: During the 20-y follow-up, 446 incident cases of asthma were identified. LC?3PUFA intake was significantly inversely associated with incidence of asthma after adjustment for sociodemographic, major lifestyle, and dietary confounders. The multivariable-adjusted HR for the highest quintile of LC?3PUFA intake as compared with the lowest quintile was 0.46 (95% CI: 0.33, 0.64; P-trend < 0.01). However, a higher frequency of nonfried fish consumption was not significantly associated with the risk of asthma. DHA showed a greater inverse association than did EPA. The association between LC?3PUFAs and incident asthma was not appreciably modified by sex, race, BMI, smoking status, or atopic status.
Conclusion: This study showed that intakes of LC?3PUFAs are inversely longitudinally associated with the incidence of asthma in American young adults.

Source: Am J Clin Nutr January 2013 vol. 97 no. 1 173-178

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