(24-10-2017) Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents

Nancy F. Krebs, MD, MS, Dexiang Gao, PhD, Jane Gralla, PhD, Juliet S. Collins, MD, and Susan L. Johnson, PhD
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Abstract

Objective

To evaluate the efficacy and safety of a carbohydrate restricted versus a low fat diet on weight loss, metabolic markers, body composition, and cardiac function tests in severely obese adolescents.

Study design

Subjects were randomized to one of two diets: a high protein, low carbohydrate (20 g/day) diet (HPLC) or low fat (30% of calories) (LF) regimen for 13 weeks; close monitoring was maintained to evaluate safety. After the intervention, no clinical contact was made until follow-up measurements were obtained at 24 and 36 weeks from baseline. The primary outcome was change in BMI-Z-score at 13, 24, and 36 weeks.

Results

Forty-six subjects (24 HPLC, 22 in LF) initiated and 33 subjects completed the intervention; follow-up data were available on approximately half of the subjects. Significant reduction in BMI-Z-score (BMI-Z) was achieved in both groups during intervention, and was significantly greater for the HPLC group (p=0.03). Both groups maintained significant BMI-Z reduction at follow-up; changes were not significantly different between groups. Loss of lean body mass was not spared in the HPLC group. No serious adverse effects were observed related to metabolic profiles, cardiac function, or subjective complaints.

Conclusions

The HPLC diet is a safe and effective option for medically supervised weight loss in severely obese adolescents.

Source: J Pediatr. Author manuscript; available in PMC 2011 Aug 1.
Published in final edited form as:
J Pediatr. 2010 Aug; 157(2): 252–258.

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