(27-02-2018) Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men

D M Dreon
1
Children’s Hospital Oakland Research Institute, CA, USA
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D M Dreon
H A Fernstrom
1
Children’s Hospital Oakland Research Institute, CA, USA
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H A Fernstrom
H Campos
1
Children’s Hospital Oakland Research Institute, CA, USA
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H Campos
P Blanche
1
Children’s Hospital Oakland Research Institute, CA, USA
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P Blanche
P T Williams
1
Children’s Hospital Oakland Research Institute, CA, USA
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P T Williams
R M Krauss
1
Children’s Hospital Oakland Research Institute, CA, USA
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R M Krauss
The American Journal of Clinical Nutrition, Volume 67, Issue 5, 1 May 1998, Pages 828–836, https://doi.org/10.1093/ajcn/67.5.828

Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men | The American Journal of Clinical Nutrition | Oxford Academic We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more
ABSTRACT
We tested whether nutrient intakes estimated from 4-d diet records were associated with plasma lipoprotein subclasses in 103 men who were randomly assigned to a low-fat (24% fat) and a high-fat (46% fat) diet for 6 wk each in a crossover design. Postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities were also determined in a subset of 43 men. Changes in intake (ie, high fat minus low fat) of total saturated fatty acids, as well as myristic (14:0) and palmitic (16:0) acids, were positively correlated (P < 0.01) with increases in mass of large LDL particles [measured by analytic ultra-centrifugation as mass of lipoproteins of flotation rate (Sf) 7-12] and with LDL peak particle diameter and flotation rate, but not with changes in LDL-cholesterol concentration. Changes in total saturated fatty acids as well as myristic and palmitic acids were also inversely associated with changes in HL activity (P < 0.05). With the high-fat diet only, variation in dietary total saturated fatty acid intake was inversely correlated (P < 0.01) with concentrations of small, dense LDL of Sf 0-5. This correlation was significant specifically for myristic acid (P < 0.001). Stearic acid (18:0), monounsaturates, and polyunsaturates showed no significant associations with lipoprotein concentrations. These data indicate that a high saturated fat intake (especially 14:0 and 16:0) is associated with increased concentrations of larger, cholesterol-enriched LDL and this occurs in association with decreased HL activity.

Source: https://academic.oup.com/ajcn/article/67/5/828/4666151

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